Synthesis of a Novel 9-O Berberine Derivative and Evaluation of Its Hypoglycemic Effect

Berberine is a phytogenic isoquinoline alkaloid which demonstrates several pharmacological effects, including hypoglycemic effect. Its medical use limited by its very low bioavailability. Synthesizing new berberine derivatives might help in overcoming this problem. In work, we report on the synthesis and biological evaluation of novel 9-O-derivative. At an oral dose 25 mg/kg, compound demonstrated activity glucose tolerance test performed using C57BL/6 mice.